Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heart

Radiation therapy (RT) is part of definitive treatment for patients with unresectable non-small cell lung cancer (NSCLC). Despite major technological advances in imaging and conformal delivery techniques, the tolerances of adjacent normal tissues continue to limit target volume doses [1,2]. In patients receiving RT for thoracic malignancies, the most frequent toxicities occur in the lungs and/or heart. Radiation-induced cardiac toxicity (RICT) may present as multiple pathologies including myocardial fibrosis, ischemic heart disease, valvular abnormalities and pericarditis [3].

Source: Radiotherapy and Oncology - July 10, 2020 Category: Radiology Authors: Mihaela Ghita, Eleanor K. Gill, Gerard M. Walls, Kevin S. Edgar, Stephen J. McMahon, Eliana Vasquez Osorio, Carmen Bergom, David J. Grieve, Chris J. Watson, Alan McWilliam, Marianne Aznar, Marcel van Herk, Kaye J. Williams, Karl T. Butterworth Tags: Original Article Source Type: research