Performance of the Steno type 1 risk engine for cardiovascular disease prediction in Italian patients with type 1 diabetes

Publication date: Available online 11 July 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Federico Boscari, Mario Luca Morieri, Anna Maria Letizia Amato, Valeria Vallone, Ambra Uliana, Anna Baritussio, Nicola Vitturi, Elisa Cipponeri, Francesco Cavallin, Angelo Avogaro, Gian Paolo Fadini, Daniela Bruttomesso
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research

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CONCLUSIONS: Type 1 diabetes in both genders and all ages was associated with significantly elevated SMRs for all-cause and mostly for diabetes per se and renal disease. PMID: 32741854 [PubMed - as supplied by publisher]
Source: Journal of Epidemiology - Category: Epidemiology Tags: J Epidemiol Source Type: research
Authors: Disoteo OE, Zampetti B, Garascia A, Attanasio R, Cozzi R Abstract A 24-yo female was admitted for acute renal failure, melanoderma, hyponatremia and hyperkalemia. The clinical suspicion of Addison's disease was confirmed by laboratory test and the appropriate replacement therapy with corticosteroids and fludrocortisone was started. In the mean-time primary hypothyroidism and diabetes mellitus type 1 were disclosed and treated, thus fulfilling a diagnosis of autoimmune polyendocrine syndrome type 2. Eighteen months later she was admitted for right sided heart failure. The work-up allowed to diagnose pulmona...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
We present the unique opportunity we had to monitor the liver, IL-6 and immune cell course before, during and after COVID-19 in a boy with autoimmune hepatitis (AIH) and type 1 diabetes (T1D). CD4+ and CD8+ T cells frequencies decreased because of prednisolone, followed by a plateauing increase whereas CD19+CD20+ B cell increased strongly and was unaffected by COVID-19 infection. Moreover, the percentage of activated CD8+ T cells expressing HLA-DR (CD8+HLA-DR+) increased during COVID-19 and subsided after its clearance. Total regulatory T cells (Tregs: CD4+CD25+CD127lowFOXP3+) remained stable. Although activated Tregs (CD4...
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Case Reports Source Type: research
ConclusionsInsulin pumps or glucose sensors appeared cost-effective, particularly in populations with higher HbA1c levels and rates of hypoglycaemia. However, cost-effectiveness for combined insulin pumps and glucose sensors was less clear.RegistrationThe study was registered with PROSPERO, number CRD42017077221.
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
Autoimmune thyroiditis frequently coexist with type 1 diabetes and additionally increases the extent of microcirculatory complications due to type 1 diabetes mellitus, but its impact on large arteries has been rarely studied. We investigated the influence of autoimmune thyroiditis on large arteries in type 1 diabetes mellitus pediatric patients. It was concluded that common carotid pulsatility is deteriorated by autoimmune thyroiditis independently of age in children with type 1 diabetes mellitus. AbstractAutoimmune thyroiditis (AIT) frequently coexists with type 1 diabetes (DM1) and additionally increases the extent of mi...
Source: Physiological Reports - Category: Physiology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Authors: Yun K, Daniels G, Gold K, Mccowen K, Patel SP Abstract Type 1 diabetes is a rare immune-related adverse event (irAE) caused by checkpoint inhibitors with serious risk for diabetic ketoacidosis (DKA). Using our electronic medical record, we identified 1327 adult patients who received PD-(L)1 or CTLA-4 inhibitors from 2013 to 2018. Of the patients who received immunotherapy, 5 (0.38%) patients were found to have type 1 diabetes, all of whom presented with DKA requiring insulin at 20 to 972 days from their first anti-PD-(L)1 dose. All patients were treated with anti-PD-1 therapy (nivolumab or pembrolizumab). ...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
ConclusionOur results suggest that post-transplant outcomes of PTx using pancreas from older donors aged  ≥ 60 years are comparable to those using pancreas from younger donors, and support expansion of the donor pool for transplantation therapy for type 1 diabetes mellitus.
Source: Surgery Today - Category: Surgery Source Type: research
Abstract Neuroinflammation and mitochondrial dysfunction are suggested as mechanisms which are implicated in the pathophysiology of depression. Streptozotocin (STZ) is known to produce immune-inflammatory responses and mitochondrial dysfunction in different types of animal models of disease (e.g. type-1 diabetes and Alzheimer's disease). Therefore, a single low dose of Streptozotocin (STZ; intracerebroventricular, i.c.v, 0.2 mg/mouse) was used to induce an animal model of depression. The present study aims to investigate the effects of short (24 h) and long (14 days) exposure to minocycline on STZ-i...
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
Publication date: Available online 31 July 2020Source: Computational and Structural Biotechnology JournalAuthor(s): Qiaoying Jiang, Hangying Xu, Junjie Yan, Qingqing Xu, Yafei Zheng, Chen Li, Liangcai Zhao, Hongchang Gao, Hong Zheng
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research
AbstractAims/hypothesisFor individuals living with type 1 diabetes, closed-loop insulin delivery improves glycaemic control. Nonetheless, maintenance of glycaemic control during exercise while a prandial insulin bolus remains active is a challenge even to closed-loop systems. We investigated the effect of exercise announcement on the efficacy of a closed-loop system, to reduce hypoglycaemia during postprandial exercise.MethodsA single-blind randomised, crossover open-label trial was carried out to compare three strategies applied to a closed-loop system at mealtime in preparation for exercise taken 90  min after eatin...
Source: Diabetologia - Category: Endocrinology Source Type: research
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