Pattern and prognosis of distant metastases in nasopharyngeal carcinoma: A large ‐population retrospective analysis

Our study shows the distribution patterns and prognoses of distant metastases among 4 histological types in NPC. A nomogram was constructed for clinical use based on 4 independent prognostic risk indicators, including histology, radiation therapy, chemotherapy and metastatic status. Our findings provide a reference for clinical decision ‐making and future diagnostic screening tests for NPC with distant metastases. AbstractCurrently, the features and prognosis of nasopharyngeal carcinoma (NPC) with distant metastases are still rarely reported. Thus, the main purpose of our study was to investigate the metastasis patterns of different histological types of NPC and to clarify the prognostic characteristics of metastases at different sites. Patients were enrolled from the SEER program from 2010 to 2016. Chi ‐squared tests were used to compare features between groups. The tendency to develop combined metastases was assessed with the odds ratio. The Kaplan‐Meier method was used for the survival analysis. Univariate and multivariate Cox analyses were used to select the independent prognostic risk fact ors for inclusion in the nomogram. In the present study, we found the following: (1) tumors are highly likely to metastasize if they have a larger volume, the regional lymph nodes are relatively large, or the regional lymph nodes are biopsied but not removed; (2) the bone and the brain were the most and least common metastatic sites among all histological types and N stages. Meta...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research