Network pharmacology and molecular docking analysis on molecular targets and mechanisms of Huashi Baidu formula in the treatment of COVID-19.

Network pharmacology and molecular docking analysis on molecular targets and mechanisms of Huashi Baidu formula in the treatment of COVID-19. Drug Dev Ind Pharm. 2020 Jul 08;:1-9 Authors: Tao Q, Du J, Li X, Zeng J, Tan B, Xu J, Lin W, Chen XL Abstract PURPOSE: Huashi Baidu formula (HSBDF) was developed to treat the patients with severe COVID-19 in China. The purpose of this study was to explore its active compounds and demonstrate its mechanisms against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through network pharmacology and molecular docking. METHODS: All the components of HSBDF were retrieved from the pharmacology database of TCM system. The genes corresponding to the targets were retrieved using UniProt and GeneCards database. The herb-compound-target network was constructed by Cytoscape. The target protein-protein interaction network was built using STRING database. The core targets of HSBDF were analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). The main active compounds of HSBDF were docked with SARS-CoV-2 and angiotensin converting enzyme II (ACE2). RESULTS: Compound-target network mainly contained 178 compounds and 272 corresponding targets. Key targets contained MAPK3, MAPK8, TP53, CASP3, IL6, TNF, MAPK1, CCL2, PTGS2, etc. There were 522 GO items in GO enrichment analysis (p 
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

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We're now more than seven months into the coronavirus pandemic that has upended the lives of most of Earth's inhabitants. And while it is true that the scientific community has learned many things about the SARS-CoV-2 virus and the disease it causes, Covid-19, there are also many gaps in our understanding.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Background Shortly after its emergence in December 2019, the coronavirus disease 2019 (COVID-19) was declared as a pandemic by the World Health Organization. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the seventh member of the Coronaviridae family of viruses that causes disease in humans. The problem Despite the established role of molecular diagnostics, COVID-19 serodiagnosis remains a poorly discovered and enigmatic area. Although there are numerous commercial serological products available globally, there is a severe paucity of high-quality peer-reviewed literature on their true performance ch...
Source: Current Opinion in Rheumatology - Category: Rheumatology Tags: RHEUMATOLOGICAL ASPECTS OF COVID-19: Edited by Leonard H. Calabrese and Cassandra Calabrese Source Type: research
Authors: Zaman S, MacIsaac AI, Jennings GL, Schlaich MP, Inglis SC, Arnold R, Kumar S, Thomas L, Wahi S, Lo S, Naismith C, Duffy SJ, Nicholls SJ, Newcomb A, Almeida AA, Wong S, Lund M, Chew DP, Kritharides L, Chow CK, Bhindi R Abstract INTRODUCTION: The coronavirus 2019 disease (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pre-existing cardiovascular disease (CVD) increases the morbidity and mortality of COVID-19, and COVID-19 itself causes serious cardiac sequelae. Strategies to minimise the risk of viral transmission to health care workers and uninfected cardiac pa...
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
How did "flatten the curve" become "flatten the economy?" A perspective from the United States of America. Asian J Psychiatr. 2020 May 13;51:102165 Authors: Jenson HB Abstract The coronavirus SARS-CoV-2 (COVID-19) pandemic offers many medical, economic, societal, and cultural challenges. The response by individual states in the United States of America varies, but with the common initial impetus for all being to "flatten the curve," which was intended to delay infections and spread the burden and impact on hospitals and medical systems. Starting with that intention, the re...
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Authors: Daeschler SC, Manson N, Joachim K, Chin AWH, Chan K, Chen PZ, Jones A, Tajdaran K, Mirmoeini K, Zhang JJ, Maynes JT, Zhang L, Science M, Darbandi A, Stephens D, Gu F, Poon LLM, Borschel GH Abstract BACKGROUND: Unprecedented demand for N95 respirators during the coronavirus disease 2019 (COVID-19) pandemic has led to a global shortage of these masks. We validated a rapidly applicable, lowcost decontamination protocol in compliance with regulatory standards to enable the safe reuse of N95 respirators. METHODS: We inoculated 4 common models of N95 respirators with severe acute respiratory syndrome coronav...
Source: Canadian Medical Association Journal - Category: General Medicine Tags: CMAJ Source Type: research
BACKGROUND: The outbreak of coronavirus disease 2019 (COVID-19), like severe acute respiratory syndrome (SARS), provokes fear, anxiety and depression in the public, which further affects mental health issues. Taiwan has used their experience of the SARS ep...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Disaster Preparedness Source Type: news
Publication date: Available online 1 August 2020Source: PhytomedicineAuthor(s): Qinhai Ma, Runfeng Li, Weiqi Pan, Wenbo Huang, Bin Liu, Yuqi Xie, Zhoulang Wang, Chufang Li, Haiming Jiang, Jicheng Huang, Yongxia Shi, Jun Dai, Kui Zheng, Xiaobo Li, Min Hui, Li Fu, Zifeng Yang
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
In this study, we proposed a random walk model to identify the potential pathological mechanisms of COVID-19 on a virus-human protein interaction network, and we effectively identified a group of proteins that have already been determined to be potentially important for COVID-19 infection and for similar SARS infections, which help further developing drugs and targeted therapeutic methods against COVID-19. Moreover, we constructed a standard computational workflow for predicting the pathological biomarkers and related pharmacological targets of infectious diseases. PMID: 32685484 [PubMed - indexed for MEDLINE]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Publication date: Available online 30 July 2020Source: Academic RadiologyAuthor(s): Sanaz Katal, Sean Johnston, Jennifer Johnston, Ali Gholamrezanezhad
Source: Academic Radiology - Category: Radiology Source Type: research
Conclusions: In the future, real-world case series of MS/NMOSD patients infected with COVID-19 will help us define the best management strategies. For the time being, we rely on expert experience and guidance.RESUMO Introdu ção: A mais recente pandemia causada pelo coronavírus SARS-CoV-2 (COVID-19, do inglês coronavirus disease 2019) representa uma ameaça potencial para pacientes com doenças autoimunes, incluindo esclerose múltipla (EM) e transtorno do espectro de neuromielite óptica (NMOSD, do inglês neuromy elitis optica spectrum disorders). Esses pacientes s&a...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
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