Systematic development and characterization of curcumin loaded nanogel for topical application.

Systematic development and characterization of curcumin loaded nanogel for topical application. Drug Dev Ind Pharm. 2020 Jul 09;:1-36 Authors: Kesharwani P, Jain A, Srivastava AK, Keshari MK Abstract Curcumin (CUR) conventional formulation has poor oral bioavailability due to low solubility and low stability. Also, it extensively undergoes first-pass-metabolism showing low biological activity. The present work focuses on the systematic development and characterization of CUR loaded Nanostructured Lipid Carrier (CUR-NLCs) having promising topical applications for skin diseases such as psoriasis. CUR-NLCs were prepared by using high-speed homogenization method. Quality by design approach was exploited to select out Critical Process Parameters i.e. Homogenization speed (X1), Homogenization time (X2), amount of lipid (X3), solid lipids (SL): liquid lipids (LL) (X4), and surfactant conc. (X5) using Plackett-Burman design and for obtaining critical quality attributes i.e. particle size (Y1) and entrapment efficiency (Y2) using Box-Behnken design. The developed NLCs were found to be nano-metric in size (189.4 ± 2.6 nm) with a low polydispersity index (0.262 ± 0.24), zeta potential (-21.45 ± 1.3 mV), and showed good encapsulation efficiency (86.72 ± 09%). Surface morphology determined by SEM and AFM revealed the spherical shape of the NLCs with a smooth surface. XRD ...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

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Publication date: Available online 29 July 2020Source: Journal of EthnopharmacologyAuthor(s): Le Kuai, Jiankun Song, Ruoxi Zhang, Meng Xing, Ying Luo, Yi Ru, Xiao-jie Ding, Liu Liu, Yi Lu, Xiaoying Sun, Hua Nian, Xin Li, Bin Li
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Roberta Cassano Psoriasis is one of the most common human skin disorders. Although its pathogenesis is complex and not completely know, the hyperactivation of the immune system seem to have a key role. In this regard, among the most effective systemic therapeutics used in psoriasis, we find cyclosporine, an immunosuppressive medication. However, one of the major problems associated with the use of cyclosporine is the occurrence of systemic side effects such as nephrotoxicity, hypertension, etc. The present work fits in this context and its aim is the design of suitable platforms for cyclosporine topical release in pso...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
AbstractActivated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of intracellular granule components that function by capturing and destroying microbes, including viral, fungal, bacterial, and protozoal pathogens. The positive effects of pathogen control are countered by pro-inflammatory effects as demonstrated in a variety of diseases. Components of NETS are non-specific, and other than controlling microbes, they cause injury to surrounding tissue by themselves or by increasing the pro-inflammatory resp...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Conclusion: The guselkumab had excellent efficacy and great safety in moderate-to-severe plaque psoriasis, but long-term safety remained to be determined. PMID: 32724829 [PubMed - in process]
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
FRIDAY, July 31, 2020 -- Thyroid dysfunction in patients with psoriasis may be associated with inflammation caused by psoriasis, according to a study published online June 22 in the Journal of Dermatology. Jianfeng Zheng, from the Tongji University...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
Conclusions and Implications: Direct and indirect comparisons and integrated results suggested that the 3 anti- tumor necrosis factor -α biologics (GOL, ETN, and IFX) can be considered the best treatments for PsA after comprehensive consideration of efficacy and safety.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research
FDA Approves Wynzora Cream for Adults with Plaque Psoriasis Plaque psoriasis is a chronic skin condition often found on the elbows, knees, scalp and lower back. It is characterized by raised, red lesions with a silvery white scale that may itch,...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
Conclusions: The results of this study revealed significantly increased risk of both prevalent and incident uveitis among patients with psoriasis. PMID: 32724820 [PubMed - as supplied by publisher]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
This study revealed that AMPs and AVPs are two important functional protein clusters altering innate immune in psoriatic epidermis. OAS2 is a novel potential sensitive biomarker, which could predict the severity and activity of psoriasis, and could also be used as an indicator to evaluate or monitor the efficacy of clinical treatment.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Psoriasis is a chronic, immune-mediated, systemic, inflammatory disorder characterized by skin plaques and, often, nail disease and arthritis that contribute to reduced quality of life. Psoriatic arthritis —a heterogeneous, inflammatory, musculoskeletal disease that can cause permanent damage to both peripheral and axial joints—is the most common comorbidity of psoriasis. Axial disease occurs in 25% to 70% of patients with PsA, with some patients exclusively experiencing axial joint involvement. E arly therapeutic intervention is important for preventing permanent joint and spine damage and loss of functionality in these patients.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: Review Source Type: research
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