Early functional MRI changes in a prodromal semantic variant of primary progressive aphasia: a longitudinal case report

ConclusionsThis case report showed longitudinal fMRI patterns during semantic-related tasks from prodromal to overt svPPA. Frontal brain recruitment may represent a compensatory mechanism in patients with early svPPA, which is likely to be reinforced by language-therapy. Brain fMRI is more sensitive compared with structural MRI to detect progressive brain changes associated with disease and treatment.

Source: Journal of Neurology - July 9, 2020 Category: Neurology Source Type: research