Drug-induced Bullous Pemphigoid and Lupus Erythematosus Occurring under Anti-TNF- α and IL-6 Therapy in a Patient with Rheumatoid Arthritis.

Drug-induced Bullous Pemphigoid and Lupus Erythematosus Occurring under Anti-TNF-α and IL-6 Therapy in a Patient with Rheumatoid Arthritis. Intern Med. 2020 Jul 07;: Authors: Yoshikawa N, Matsubara E, Yamamoto M, Yamazaki H, Uehara M, Kamata M, Tanaka H Abstract A 65-year-old Japanese woman, who was diagnosed with rheumatoid arthritis and Sjögren's syndrome with various autoantibodies including anti-DNA antibody, developed bullous pemphigoid and hematological abnormalities like lupus erythematosus after adalimumab therapy. The discontinuation of adalimumab resolved those disorders but polyarthritis thereafter relapsed. The introduction of abatacept was not effective, but tocilizumab was found to be effective for polyarthritis, however, thereafter both bullous disease and severe pancytopenia developed. Discontinuation of tocilizumab was effective, but polyarthritis again developed, and baricitinib resolved it. There is an increasing number of reports of drug-induced bullous pemphigoid and lupus erythematosus, and biologics might trigger an alteration in the pathophysiological/clinical course of rheumatic disorder. PMID: 32641647 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research