Mitochondrial Haplogroup Reveals the Genetic Basis of Diabetes Mellitus Type 2 Comorbidity in Psoriasis

Objective: Published data has shown a clear link between psoriasis (Ps) and the increasing prevalence of comorbid conditions, such as diabetes mellitus type 2 (DM2). The mitochondrial genomic haplogroup's role in the potential coexistence of psoriasis and DM2 comorbidity is the subject of this study. Material and method: Ninety-eight Kuwaiti individuals were recruited in 4 cohorts (20 healthy controls (HC), 15 with DM2, 34 with psoriasis, and 29 with psoriasis and diabetes mellitus (PsDM2). An Ion Torrent S5xL was used to sequence mitochondrial DNA (mtDNA). Chi-square test (x2) was used to assess differences in the distribution of each haplogroup between cases and controls (p
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research