Daratumumab for Treatment of Antibody-Mediated Rejection after ABO-Incompatible Kidney Transplantation

We report the effectiveness of daratumumab, a human IgG κ monoclonal antibody targeting CD38 on plasma cells, for therapy-refractory antibody-mediated rejection (AMR) due to blood group antibodies in a 59-year-old man who received a living ABO-incompatible kidney transplantation. Standard treatment options for AMR due to blood group antibodies including immunoadsorption, lymphocyte depletion with anti-human T-lymphocyte globulins, intravenous methylprednisolone pulses and eculizumab limited tissue injury, however failed to sufficiently suppress blood group antibody production. After administration of daratumumab as a rescue therapy, blood group an tibody titers decreased and remained at low levels without further immunoadsorption and allowed kidney graft function to recover.Case Rep Nephrol Dial 2019;9:149 –157
Source: Case Reports in Nephrology and Dialysis - Category: Urology & Nephrology Source Type: research