Retinal layers changes in patients with diabetic macular edema treated with intravitreal anti-VEGF agents: Long-term outcomes of a spectral-domain OCT study

Purpose: The purpose of this study is to investigate retinal layers ’ changes in patients with diabetic macular edema (DME) treated with anti-vascular endothelial growth factor (anti-VEGF) agents and to evaluate if these changes may affect treatment response. Methods: Participants in this prospective study were 110 treatment-naïve patients with center involved D ME, who were treated with anti-VEGF agents and followed-up for at least 12 months. A qualitative and quantitative analysis of retinal layers that can affect visual acuity was performed. Patients with persistent DME were defined and factors, which could affect this outcome, were determined. Results: Visual acuity was significantly improved, while there was also a statistically significant reduction in central retinal thickness and in all separate retinal layers’ thickness at month 12 compared to baseline (p
Source: Ophthalmic Research - Category: Opthalmology Source Type: research