Immunoglobulins G Modulate Endothelial Function and affect Insulin Sensitivity in Humans

Data from animals suggest that immunoglobulins G (IgG) play a mechanistic role in atherosclerosis and diabetes through endothelial dysfunction and insulin resistance. Patients with common variable immunodeficiency (CVID), who have low circulating levels of IgG and are treated with intravenous polyclonal IgG (IVIgG), may provide an ideal model to clarify whether circulating IgG modulate endothelial function and affect insulin sensitivity in humans.

Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 9, 2020 Category: Nutrition Authors: Raffaele Napoli, Antonio Ruvolo, Paola Triggianese, Nella Prevete, Gabriele G. Schiattarella, Cecilia Nigro, Claudia Miele, Fabio Magliulo, Simona Grassi, Antonio Pecoraro, Antonio Cittadini, Giovanni Esposito, Amato de Paulis, Giuseppe Spadaro Source Type: research