Tumor suppressor p53 regulates insulin receptor (INSR) gene expression via direct binding to the INSR promoter.
Tumor suppressor p53 regulates insulin receptor (INSR) gene expression via direct binding to the INSR promoter. Oncotarget. 2020 Jun 23;11(25):2424-2437 Authors: Sarfstein R, Werner H Abstract A significant volume of clinical and epidemiological data provides support to the concept that insulin and the insulin receptor (INSR) have an important role in breast cancer. Tumor suppressor p53 is the most frequently mutated molecule in human cancer. The present study was aimed at evaluating the hypothesis that p53 governs the expression and activation of the INSR gene in breast cancer cells. In addition, the study was designed to investigate the mechanism of action of p53 in the context of INSR gene regulation. The availability of MCF7 breast cancer-derived cell lines with specific disruption of either the insulin-like growth factor-1 receptor (IGF1R) or INSR allowed us to address the impact of the IGF1R and INSR pathways on p53 expression. Data indicate that the INSR gene constitutes a target for p53 action. Wild-type p53 stimulated INSR promoter activity in control cells while disruption of endogenous IGF1R or INSR led to inhibition of promoter activity by p53. Mutant p53 strongly stimulated INSR promoter. Furthermore, p53 directly binds to the INSR promoter in cells with a disrupted IGF1R. Combined, our results identified complex functional and physical interactions between p53 and the INSR pathway. The implications of the p53-INSR interplay in breast cancer ...
Conclusion This meta-analysis suggested that ALB was positively associated with the risk of breast cancer. The risk of developing breast cancer increased gradually with the ALB for women. Our findings may have implications for family planning.
We investigated whether plasma oxidative stress and apoptotic biomarkers were associated with the VDR polymorphisms in breast cancer survivors supplemented with vitamin D3. Two hundred fourteen breast cancer survivors received 4000 IU of vitamin D3 daily for 12 weeks. Linear regression was used to analyze whether the effect of vitamin D3 supplementation on response variables was associated with the selected VDR single nucleotide polymorphisms executing by ‘association’ function in the R package ‘SNPassoc’. Linear regression analyses adjusted for age, BMI and on-study plasma 25(OH)D changes indicated...
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Condition: Breast Cancer Intervention: Drug: Tocotrienol Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano Completed
Conclusions: The use of a mixed methods approach (qualitative and quantitative data) to evaluating the outcomes perceived by a group of women with breast cancer after participating in a Renewing Life Retreat offers insights into the unique experience of these women. PMID: 32738038 [PubMed - as supplied by publisher]
New research out of Duke University could help the thousands of Americans stricken with breast cancer. According to new research conducted at the Duke Cancer Institute, a vaccine developed at the university for breast cancer is part of an "effective" two-drug strategy for fighting against the disease. This week, research conducted through a clinical trial at Duke was published in Clinical Cancer Research – a journal of the American Association for Cancer Research. According to that research,…
(University of Cambridge) Four stranded DNA structures - known as G-quadruplexes - have been shown to play a role in certain types of breast cancer for the first time, providing a potential new target for personalised medicine, say scientists at the University of Cambridge.
Publication date: Available online 1 August 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Meilin Shi, Fengmei Zuo, Yingkai Tao, Yawen Liu, Jiahui Lu, Shaohui Zheng, Jiao Lu, Pingfu Hou, Jingjing Li, Kai Xu