Development of 64Cu-loaded Perfluoropentane Nanodroplet: A Potential Tumor Theragnostic Nano-carrier and Dual-Modality PET-Ultrasound Imaging Agents

The purpose of this study was to develop and preliminarily evaluate phospholipid-shelled nanodroplets (NDs) encapsulating perfluoropentane (PFP) and radioactive 64Cu as a hybrid positron emission tomography (PET)-ultrasound (US) probe.  PFP NDs were fabricated by mixing liquid-phase PFP with a phospholipid solution. The 64Cu was encapsulated into the NDs in a size-controlled manner by exploiting the hydrophobicity of 64Cu-diacetyl-bis(N4-methylthiosemicarbazone) (64Cu-ATSM) using a vial mixer and an extruder.

Source: Ultrasound in Medicine and Biology - July 8, 2020 Category: Radiology Authors: Unchol Shin, Jungyoung Kim, Jiwoong Lee, Donghee Park, Changmoon Lee, Hyon Chel Jung, Jiae Park, Kyochul Lee, Min Woo Lee, Suhng Wook Kim, Jongbum Seo Tags: Original Contribution Source Type: research