Newborn Iodine Status Not Tied to Congenital Hypothyroidism

THURSDAY, July 9, 2020 -- Blood iodine concentrations in newborns do not vary for infants with or without congenital hypothyroidism (CH), although they are higher in cases versus controls in the neonatal intensive care unit (NICU), according to a...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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ConclusionWe propose that DNAJC3 mutation can be considered as a cause of maturity onset diabetes of the young. Patients with DNAJC3 mutations may possess a small atrophic pancreas.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
CONCLUSIONS: The duration between MI and CABG has a direct influence on outcomes after CABG. While it is clear that the longer the duration between MI and CABG, the lower the mortality risk, it is however difficult to decide on an exact cut-off time frame.PMID:34552641 | PMC:PMC8442093 | DOI:10.5114/kitp.2021.105184
Source: Polish Journal of Cardio-Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
Curr Med Res Opin. 2021 Sep 23:1. doi: 10.1080/03007995.2021.1984219. Online ahead of print.ABSTRACTThe current guideline-based management of hypothyroidism recommends monotherapy with levothyroxine (LT4), titrated to maintain the level of thyrotropin within a euthyroid reference range. This has been successful for most people with hypothyroidism, but a substantial minority still report symptoms of hypothyroidism unexplained by a comorbid medical condition. LT4 is essentially a prodrug for triiodothyronine (T3), the thyroid hormone that acts on target tissues in the brain and the periphery. Thyroid hormone replacement with...
Source: Current Medical Research and Opinion - Category: Research Authors: Source Type: research
CONCLUSIONS: The duration between MI and CABG has a direct influence on outcomes after CABG. While it is clear that the longer the duration between MI and CABG, the lower the mortality risk, it is however difficult to decide on an exact cut-off time frame.PMID:34552641 | PMC:PMC8442093 | DOI:10.5114/kitp.2021.105184
Source: Polish Journal of Cardio-Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
The clinical complications of congenital hypothyroidism such as brain disorders are very subtle and are not recognizable in infancy period. They are recognizable when it is too late for treatment or prevention...
Source: Orphanet Journal of Rare Diseases - Category: Internal Medicine Authors: Tags: Research Source Type: research
Conclusion: Pazopanib was found a feasible treatment option for M-STS in India with internationally comparable outcomes. However, significant patients required dose modifications, and median tolerated dose was lower than the standard 800 mg dose. This novel finding merits confirmation in larger cohorts for reproducibility.
Source: Indian Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
Endocr J. 2021 Sep 18. doi: 10.1507/endocrj.EJ21-0340. Online ahead of print.ABSTRACTA 28-year-old Japanese woman positive for TSH receptor antibody and anti-nuclear antibody complained of difficulty seeing nearby objects, severe throbbing retro-orbital pain, diplopia, blepharoptosis and upward gaze palsy when she became hypothyroid during treatment with 30 mg methylmercaptoimidazole for Graves' hyperthyroidism. Brain magnetic resonance imaging revealed slightly swollen bilateral inferior rectus muscles, suggesting the external ophthalmoplegia due to the muscle pathology commonly encountered in Graves' disease. The retro-o...
Source: Endocrine Journal - Category: Endocrinology Authors: Source Type: research
CONCLUSION: Our study indicated that the prevalence of SLC26A4 mutations was 3.66% in the Chinese patients with CH. Five mutations (p.I363L, p.R409H, p.T485M, p.D661E and p.H723R) impaired the membrane location or ion transport function of SLC26A4,which revealed important role of the Ile363,Arg409, Thr485, Asp661, His723 residues in function of SLC26A4. Because these mutations are heterozygous mutations, the pathogenesis of these patients cannot be explained, and the pathogenesis of these patients needs further study.PMID:34545167 | DOI:10.4274/jcrpe.galenos.2021.2021.0122
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Authors: Source Type: research
Endocr J. 2021 Sep 18. doi: 10.1507/endocrj.EJ21-0340. Online ahead of print.ABSTRACTA 28-year-old Japanese woman positive for TSH receptor antibody and anti-nuclear antibody complained of difficulty seeing nearby objects, severe throbbing retro-orbital pain, diplopia, blepharoptosis and upward gaze palsy when she became hypothyroid during treatment with 30 mg methylmercaptoimidazole for Graves' hyperthyroidism. Brain magnetic resonance imaging revealed slightly swollen bilateral inferior rectus muscles, suggesting the external ophthalmoplegia due to the muscle pathology commonly encountered in Graves' disease. The retro-o...
Source: Endocrine Journal - Category: Endocrinology Authors: Source Type: research
CONCLUSION: Our study indicated that the prevalence of SLC26A4 mutations was 3.66% in the Chinese patients with CH. Five mutations (p.I363L, p.R409H, p.T485M, p.D661E and p.H723R) impaired the membrane location or ion transport function of SLC26A4,which revealed important role of the Ile363,Arg409, Thr485, Asp661, His723 residues in function of SLC26A4. Because these mutations are heterozygous mutations, the pathogenesis of these patients cannot be explained, and the pathogenesis of these patients needs further study.PMID:34545167 | DOI:10.4274/jcrpe.galenos.2021.2021.0122
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Authors: Source Type: research
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