Hydroa vacciniforme-like lymphoproliferative disorder: A study of clinicopathology and whole-exome sequencing in Chinese patients

Hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) encompasses a group of chronic Epstein-Barr virus (EBV)-associated lymphoproliferative diseases characterized by papulovesicular skin lesions [1]. However, dermatologists and oncologists have limited clinical experience with this disease because HVLPD is relatively rare with an obvious difference in regional distribution, as it is more common in Asia [2] and Latin America [3,4] than in the United States and Europe. Moreover, HVLPD often manifests as diverse skin lesions, with frequent atypical cases, and the clinical manifestations often deviate from the pathological manifestations; that is, although the clinical manifestations include invasive activity, atypia is often absent when tumor cells are histopathologically evaluated [5].
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research