Evolution of the mutation rate across primates.

Evolution of the mutation rate across primates.
Curr Opin Genet Dev. 2020 Jul 04;62:58-64
Authors: Chintalapati M, Moorjani P
Abstract
Germline mutations are the source of all heritable variation. In the past few years, whole genome sequencing has allowed direct and comprehensive surveys of mutation patterns in humans and other species. These studies have documented substantial variation in both mutation rates and spectra across primates, the causes of which remain unclear. Here, we review what is currently known about mutation rates in primates, highlight the factors proposed to explain the variation across species, and discuss some implications of these findings on our understanding of the chronology of primate evolution and the process of mutagenesis.
PMID: 32634682 [PubMed - as supplied by publisher]

Source: Current Opinion in Genetics and Development - July 3, 2020 Category: Genetics & Stem Cells Authors: Chintalapati M, Moorjani P Tags: Curr Opin Genet Dev Source Type: research