Changrui enema inhibits inflammation-induced angiogenesis in acute radiation proctitis by regulating NF- κB and VEGF.

CONCLUSIONS: Changrui enema is an effective treatment with fewer side effects for ARP. The mechanism of Changrui enema may be related to the inhibition of inflammation-induced angiogenesis. Changrui enema inhibits IL-1β and NF-κB expression as well as VEGF expression. Interestingly, AQP1 promotes angiogenesis, while AQP3 inhibits inflammation. Changrui enema probably inhibits AQP1 expression by down-regulating p-ERK1/2, and improves AQP3 expression by up-regulating p-JNK.
PMID: 32638843 [PubMed - in process]

Source: Acta Cirurgica Brasileira - July 5, 2020 Category: Surgery Authors: Gao J, Li Y, Yang X, Hu M, Xu J, Cheng L, Cao K, Liu L, Wang X Tags: Acta Cir Bras Source Type: research