C. elegans ACAT regulates lipolysis and its related lifespan in fasting through modulation of the genes in lipolysis and insulin/IGF ‐1 signaling

AbstractOverly active acyl ‐coenzyme A: cholesterol acyltransferases (ACATs) are known to contribute to the development of atherosclerosis, cancer cell proliferation and de novo lipogenesis. However, the role of ACAT in systemic lipid metabolism and its consequence of aging is unknown. Using avasimibe, a clinically proven A CAT inhibitor, andmboa ‐1 mutant strain, a homologous to mammalianACAT, herein, we found that Ava treatment andmboa ‐1 mutant exhibited a decreased fat accumulation during feeding and increased lipolysis with extended lifespan ofC. elegans during fasting. Our study highlights the essential role of ACAT inhibitor andmboa ‐1 in fat mobilization and the survival ofC. elegans in fasting through the modulation of the genes involved in lipolysis and insulin/IGF ‐1 signaling.
Source: BioFactors - Category: Biochemistry Authors: Tags: Research Communication Source Type: research