A Two-Step Synthesis of a Novel 7,8-Dihydro-5,8-ethanoindolizine-6,9(5H)-dione

Synlett DOI: 10.1055/s-0040-1707182 A two-step synthesis of the novel 5,8-dimethyl-7,8-dihydro-5,8-ethanoindolizine-6,9(5H)-dione from 2,3-dimethyl-1,4-benzoquinone is described. The key step of the synthesis of this unusual fused tricyclic system is the intramolecular regiospecific aza-Michael addition of a pyrrole to an activated double bond by reaction with tetrabutylammonium fluoride under mechanochemical conditions. [...] © Georg Thieme Verlag Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - July 7, 2020 Category: Chemistry Authors: Gallardo-Alfonzo, Salvador Cort és-Garcia, Carlos Jesus Mej ía-Farfán, Itzel L ópez, Yliana Mojica, Martha Contreras-Celed ón, Claudia Chac ón-García, Luis Tags: cluster Source Type: research