Recent Trends in the Development of Peptide and Protein-based Hydrogel Therapeutics for Healing of CNS Injury

Soft Matter, 2020, Accepted Manuscript DOI: 10.1039/D0SM00885K, Review ArticleNabanita Mukherjee, Anindya Sundar Adak, Surajit Ghosh Traumatic brain injury (TBI) and spinal cord injury (SCI) causes millions of death and permanent or prolonged physical disabilities around the globe every year. It generally happens due to various... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Soft Matter latest articles - Category: Chemistry Authors: Source Type: research

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Credit: Nidwan.By Pratima GurungKATHMANDU, Jul 28 2020 (IPS) In Nepal the COVID-19 crisis has been especially hard on indigenous peoples. We had to learn a new vocabulary and use words like quarantine, self-isolation, hand sanitizers and social distancing. We also had to respect rules that did not previously apply to our lives. Indigenous peoples are not used to washing their hands all the time because our culture is so much closer to Mother Earth and because much of the time we don’t have running water. The situation has been even more difficult for indigenous persons with a disability, like me. I cannot keep my so...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Asia-Pacific Headlines Health Human Rights Indigenous Rights Source Type: news
This report reviewed the correlation between mTOR and autophagy, as well as autophagy's role and the therapeutic effects of VPA in SCI. VPA regulates autophagy by potentially inhibiting mTORC1, a complex of mTOR, while also hindering inflammatory response. Conclusively, an effective treatment for SCI could lie in the timely regulation of mTOR signaling pathway, and VPA could be the potential drug that improves SCI owing to its propensity to regulate the mTOR signaling pathway. PMID: 32725456 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Neurobiology - Category: Cytology Authors: Tags: Cell Mol Neurobiol Source Type: research
Abstract Hyperbaric oxygen preconditioning (HBO-PC) has beneficial effects on the promotion of locomotor recovery by reducing apoptosis and inflammation after traumatic spinal cord injury (SCI). The mammalian target of rapamycin (mTOR) signaling pathway has been implicated in apoptosis and inflammation in many pathophysiological conditions. However, whether HBO-PC improves traumatic SCI-induced locomotor dysfunction by regulating the mTOR signaling pathway and its downstream molecules remains unknown. In the present study, we found that HBO-PC significantly promoted SCI-induced hind-limb locomotor recovery and inc...
Source: Cellular and Molecular Neurobiology - Category: Cytology Authors: Tags: Cell Mol Neurobiol Source Type: research
DISCUSSION: Our findings reveal a role for hOEC-derived EVs in NPC proliferation and oxidative stress-induced neuronal toxicity model. These results may be useful for developing non-cell therapy OEC-EV-based treatment in acquired nervous system disease. PMID: 32700620 [PubMed - as supplied by publisher]
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
Spinal cord injury (SCI) is a catastrophic injury that can cause irreversible motor dysfunction with high disability. Exosomes participate in the transport of miRNAs and play an essential role in intercellular...
Source: Journal of Nanobiotechnology - Category: Nanotechnology Authors: Tags: Research Source Type: research
ConclusionPain is a prevalent and disabling non ‐motor symptom in NMO‐SCI. Most patients experience more than one pain syndrome which can change in time even in the absence of clinical relapse. Age of the inflammatory‐SCI was a major determinant of pain. Acknowledging temporal changes and multiplicity of pain syndromes in NMO‐SCI may give insights into more precise designs of clinical trials and general management of pain in SCI.SignificanceIn this longitudinal study with NMO ‐related SCI, pain affected almost three‐quarters of patients with NMO. Over 70% have more than one pain syndrome and at‐level neuropat...
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Authors: Luo C, Tao L Abstract Spinal cord injury (SCI) is one of the major causes of death and long-term disability in the world. Numerous studies have reported that autophagy plays an important role in SCI. However, the understanding of underlying mechanisms of autophagy after SCI and autophagy mechanism-based preclinical pharmacological intervention needs to be updated. This part provides an overview of current knowledge about the mechanisms of autophagy and autophagy flux as well as its potential molecular mechanisms based on the pharmacological regulation of autophagy. Although autophagic activation and the di...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
In this study, we found that the expression and distribution of HAX-1 in neurons increased 1 day after SCI. PC12 cells overexpressing HAX-1 showed decreased apoptosis and PC12 cells are more likely to undergo apoptosis after down-regulating HAX-1, which was confirmed via TUNEL experiments. We found GRP94 showed the same trend as HAX-1 in expression and interacted with HAX-1 and IRE-1 in both spinal cord tissue and PC12 cells, and this interaction seems to be enhanced after SCI. When the expression of HAX-1 was up-regulated, GRP94 also increased, but IRE-1 did not change at all. Further studies showed that overexpressi...
Source: Neurochemical Research - Category: Neuroscience Authors: Tags: Neurochem Res Source Type: research
Authors: Chen G, Li J, Wang Z, Liu W Abstract Spinal cord injury (SCI) is a severe traumatic disease of the central nervous system characterized by high incidence and disability rate. We aimed to investigate the therapeutic potential of Ezetimibe (Eze) in SCI and identify the underlying mechanisms. Acute SCI rat model was established by using the modified weight-drop method. Following administration with Eze, the neurological function was evaluated using the Basso, Beattie, and Bresnahan (BBB) locomotor scale score, and the motor neurons were stained with Nissl staining. The pathological changes of spinal cord tiss...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
One of my most popular posts ever is one I wrote many years ago on malingering. Secondary gain, like malingering or symptom magnification is one of those terms used by people who don’t live with persistent pain, and commonly used when a person with pain doesn’t seem to be progressing “as expected”. The term is an old one, originating in the psychoanalytic literature, brought into compensation and insurance environments but never really examined (Fishbain, Rosomoff, Cutler &Rosomoff, 1995) until well after it had become a popular label. Freud first identified the potential for gains from bein...
Source: HealthSkills Weblog - Category: Anesthesiology Authors: Tags: Assessment Chronic pain Professional topics Research malingering secondary gain stigma Source Type: blogs
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