Daudi cell stroma: An alternative to dithiothreitol to resolve daratumumab interference in pretransfusion testing.

CONCLUSIONS: Daudi cell stroma is inexpensive, easy to prepare in large batches, and can be used as an off-the-shelf reagent. Incubation of plasma from DARA-treated patients with Daudi cell stroma can efficiently overcome DARA interference in serologic testing without affecting DTT- or trypsin-sensitive antigens.
PMID: 32632934 [PubMed - as supplied by publisher]

Source: Transfusion - July 5, 2020 Category: Hematology Authors: Tremblay T, Branch DR, Loubaki L Tags: Transfusion Source Type: research