Chikungunya virus infection induces differential inflammatory and antiviral responses in human monocytes and monocyte-derived macrophages.

In conclusion, our data provides evidence that CHIKV infection activates the TLR pathways in primary monocytes and MDMs, which play a crucial role in CHIKV pathogenesis and/or host defense, differentially. However, additional studies are required to determine the functional role of TLRs in monocytes and MDMs. PMID: 32634389 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32634389?dopt=Abstract

Source: Acta Tropica - July 3, 2020 Category: Infectious Diseases Authors: Felipe VLJ, Paula A V, Silvio UI Tags: Acta Trop Source Type: research