Comparison between coagulation factor VIII quantified with one-stage activity assay and with mass spectrometry in haemophilia A patients: Proof of principle.

CONCLUSIONS: Despite good overall correlation between the two methods, relative differences were large, especially for samples with anti-FVIII antibodies or exogenous FVIII products. These differences may have clinical impact. More research is needed to determine the value of FVIII plasma concentration in comparison with FVIII activity.
PMID: 32633067 [PubMed - as supplied by publisher]

Source: International Journal of Laboratory Hematology - July 5, 2020 Category: Hematology Authors: Donners AAMT, van Maarseveen EM, Weetink YRJ, El Amrani M, Fischer K, Rademaker CMA, Egberts TCG, Huisman A, Musson REA Tags: Int J Lab Hematol Source Type: research