The role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases.
The role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases.
Curr Pharm Des. 2020 Jul 07;:
Authors: Martinez GP, Zabaleta ME, Di Giulio C, Charris JE, Mijares MR
Abstract
Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of the heterocyclic aromatic compound quinoline. These economical compounds were used as antimalarial agents for many years. Currently, they are used as monotherapy or in conjunction with other therapies for the treatment of autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren's syndrome (SS) and antiphospholipid antibody syndrome (APS). Based on its effects on the modulation of the autophagy process, various clinical studies suggest that CQ and HCQ could be used in combination with other chemotherapeutics for the treatment of various types of cancer. Furthermore, the antiviral effects showed against Zika, Chikungunya, and HIV are due to the annulation of endosomal/lysosomal acidification. Recently, CQ and HCQ were approved for The U.S. Food and Drug Administration (FDA) for the treatment of infected patients with the coronavirus SARS-CoV-2, causing the disease originated in December 2019, namely COVID-2019. Several mechanisms have been proposed to explain the pharmacological effects of these drugs: 1) disruption of lysosomal and endosomal pH, 2) inhibition of protein secretion/expression, 3) inhibition of antigen presentation, 4) decreas...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Martinez GP, Zabaleta ME, Di Giulio C, Charris JE, Mijares MR Tags: Curr Pharm Des Source Type: research
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