PTPN2 Regulates Interactions Between Macrophages and Intestinal Epithelial Cells to Promote Intestinal Barrier Function.

The mechanisms by which macrophages regulate intestinal epithelial cell (IEC) barrier properties are poorly understood. Protein tyrosine phosphatase non-receptor type 2 (PTPN2) protects the IEC barrier from inflammation-induced disruption and regulates macrophage functions. We investigated whether PTPN2 controls interactions between IECs and macrophages to maintain intestinal barrier function.

Source: Gastroenterology - July 7, 2020 Category: Gastroenterology Authors: Marianne R. Spalinger, Anica Sayoc-Becerra, Alina N. Santos, Ali Shawki, Vinicius Canale, Moorthy Krishnan, Anna Niechcial, Nicole Obialo, Michael Scharl, Jiang Li, Meera G. Nair, Declan F. McCole Source Type: research