Synthesis of hyaluronic acid oligosaccharides with a GlcNAc –GlcA repeating pattern and their binding affinity with CD44

Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01048K, PaperChe-Jui Yeh, Medel Manuel L. Zulueta, Yaw-Kuen Li, Shang-Cheng Hung A practical route for the synthesis of hyaluronic acid oligosaccharides was developed, and a tetrasaccharide (GlcNAc –GlcA)2 was identified as the minimum length that binds to human CD44 (KD = 3.5 μM) using isothermal titration calorimetry. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Organic and Biomolecular Chemistry - July 8, 2020 Category: Molecular Biology Authors: Che-Jui Yeh Source Type: research