The role of the non ‐neuronal cholinergic system in inflammation and degradation processes in osteoarthritis

ConclusionThe non ‐neuronal cholinergic system is functionally expressed in chondrocytes. Stimulation of nAChR induces anti‐inflammatory and anti‐catabolic activity through α7nAChR, but the anti‐catabolic activity may be mitigated by truncated α7nAChR in human chondrocytes.In vivo experiments strongly suggest that α7nAChR has a protective role in OA.

Source: Arthritis and Rheumatology - July 7, 2020 Category: Rheumatology Authors: Alice Courties, Ariane Do, Sarah Leite, Manon Legris, Laure Sudre, Audrey Pigenet, Juliette Petit, Geoffroy Nourissat, Adeline Cambon ‐Binder, Uwe Maskos, Francis Berenbaum, Jérémie Sellam Tags: FULL LENGTH Source Type: research