The Immune Microenvironment in Young Patients with Triple Negative Breast Cancer

Purpose: Triple negative breast cancers (TNBC) comprise 15 –20% of breast cancers and are associated with adverse outcomes; the prognosis for younger women is worse [1,2]. Tumour-infiltrating lymphocytes (TILs) significantly correlate with improved survival in many cancers [3]. Conversely, tumour cell expression of PD-L1 is associated with T-cell exhausti on and is commonly a negative prognostic marker [4]. Mechanisms suppressing the immune response in TNBC remain unclear.

Source: Clinical Oncology - July 8, 2020 Category: Radiology Authors: H. McKenzie, G. Martland, M. Ellis, D. Eccles, S. Harris, S. Thirdborough, E. Copson, G. Thomas Source Type: research