Leptomeningeal Disease in Breast Cancer, Bristol Experience

Purpose: Diagnosis of leptomeningeal disease (LMD) in breast cancer patients is associated with poor prognosis [1]; median overall survival is usually less than 12 months. Diagnosis of LMD can be elusive and requires a high level of clinical suspicion. Cerebrospinal fluid (CSF) cytology is considered the gold standard to diagnose LMD but lack of malignant cells in CSF even in symptomatic patients can be a diagnostic dilemma [2]. Magnetic resonance imaging (MRI) of the head can help diagnose LMD.

Source: Clinical Oncology - July 8, 2020 Category: Radiology Authors: G. Gullick, V. Mohan, L. Gibbs, C. Comins, J. Braybrooke, J. Jenkins, A. Bahl, C. Caws Source Type: research