Venetoclax in association with decitabine as effective bridge to transplant in a case of relapsed early T ‐cell lymphoblastic leukemia

A case of an early ‐relapsed high‐risk T‐ALL with high BCL‐2 expression on leukemic blasts was successfully treated with decitabine and venetoclax, achieving a CR. We suggest decitabine and venetoclax should be synergistic in BCL2‐positive ALL. AbstractA case of an early ‐relapsed high‐risk T‐ALL with high BCL‐2 expression on leukemic blasts was successfully treated with decitabine and venetoclax, achieving a CR. We suggest decitabine and venetoclax should be synergistic in BCL2‐positive ALL.

Source: Clinical Case Reports - July 6, 2020 Category: General Medicine Authors: Elisabetta Zappone, Emanuele Cencini, Marzia Defina, Anna Sicuranza, Alessandro Gozzetti, Sara Ciofini, Donatella Raspadori, Bianca Mecacci, Monica Bocchia Tags: CASE REPORT Source Type: research