Rotenone restrains colon cancer cell viability, motility and epithelial ‑mesenchymal transition and tumorigenesis in nude mice via the PI3K/AKT pathway.

In conclusion, the present study revealed that rotenone inhibited CC cell viability, motility, EMT and metastasis in vitro and in vivo by inhibiting the PI3K/AKT/mTOR signaling pathway.
PMID: 32626924 [PubMed - in process]

Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Xiao W, Liu Y, Dai M, Li Y, Peng R, Yu S, Liu H Tags: Int J Mol Med Source Type: research