TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse model of MDS

The myelodysplastic syndromes are a group of hematopoietic stem and progenitor cell (HSPC) disorders characterized by abnormal hematopoiesis and a high risk of transformation to acute leukemia.1,2 Numerous prior studies have described enhanced innate immune signaling, and in particular, increased toll like receptor (TLR) signaling, in the CD34+ stem and progenitor cells of patients with MDS.3-11 This enhanced TLR signaling is thought to contribute to the ineffective hematopoiesis and cell death that is a prominent feature of lower-risk disease.

Source: Experimental Hematology - July 7, 2020 Category: Hematology Authors: Darlene A. Monlish, Zev J. Greenberg, Sima T. Bhatt, Kathryn M. Leonard, Molly P. Romine, Qian Dong, Lauren Bendesky, Eric J. Duncavage, Jeffrey A. Magee, Laura G. Schuettpelz Source Type: research