WWP2 regulates SIRT1-STAT3 acetylation and phosphorylation involved in hypertensive angiopathy.

In conclusion, WWP2 modulates hypertensive angiopathy by regulating SIRT1-STAT3 and WWP2 suppression in VSMCs can alleviate hypertensive angiopathy vitro and vivo. These findings provide new insights into the treatment of hypertensive vascular diseases.
PMID: 32627301 [PubMed - as supplied by publisher]

Source: J Cell Mol Med - July 4, 2020 Category: Molecular Biology Authors: Zhang Y, You S, Tian Y, Lu S, Cao L, Sun Y, Zhang N Tags: J Cell Mol Med Source Type: research