Steroid-associated bradycardia in a newly diagnosed B precursor acute lymphoblastic leukemia patient with Holt & #8211;Oram syndrome

We report a pediatric patient clinically diagnosed with HOS (missing thumbs bilaterally, atrial septal defect, ventricular septal defect, and first-degree heart block), who also developed B precursor acute lymphoblastic leukemia. During induction of chemotherapy with steroids, she developed profound bradycardia without clinical symptoms. The bradycardia resolved without intervention, but this case highlights the challenges of managing chemotherapy side effects in a patient with congenital heart disease. A literature review pertinent to the associated findings in the case is also presented.
Source: Annals of Pediatric Cardiology - Category: Cardiology Authors: Source Type: research