Upregulated proteoglycan-related signaling pathways in fluid flow shear stress-treated podocytes.
This study demonstrates the potential of the IMPRes method to identify novel pathways. Identifying the "Proteoglycans in cancer" and "Galactose metabolism" pathways generated a lead to study the significance of FFSS-induced glycocalyx remodeling and possible detachment of podocytes from the glomerular matrix.
PMID: 32628542 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Srivastava T, Joshi T, Jiang Y, Heruth DP, Rezaiekhaligh MH, Novak J, Staggs VS, Alon US, Garola RE, El-Meanawy A, McCarthy ET, Zhou J, Boinpelly VC, Sharma R, Savin VJ, Sharma M Tags: Am J Physiol Renal Physiol Source Type: research