Association between nocturnal hypoxemia and cancer incidence in patients investigated for obstructive sleep apnea. Data from a large multicenter French cohort.

Association between nocturnal hypoxemia and cancer incidence in patients investigated for obstructive sleep apnea. Data from a large multicenter French cohort.
Chest. 2020 Jul 03;:
Authors: Justeau G, Gervès-Pinquié C, Le Vaillant M, Trzepizur W, Meslier N, Goupil F, Pigeanne T, Launois S, Leclair-Visonneau L, Masson P, Bizieux-Thaminy A, Humeau MP, Gosselin C, Blanchard M, Urban T, Gagnadoux F, ERMES study group
Abstract
BACKGROUND: Previous studies have yielded inconsistent findings regarding the association between obstructive sleep apnea (OSA) and cancer in humans.
RESEARCH QUESTION: Is there an association between indices of sleep-disordered breathing severity and cancer incidence in patients investigated for suspected OSA?
STUDY DESIGN AND METHODS: Data from a large multicenter cohort of cancer-free patients investigated for OSA were linked to health administrative data to identify new-onset cancer. Kaplan-Meier survival analysis and Cox proportional-hazards models were used to evaluate the association of cancer incidence with OSA severity and nocturnal hypoxemia.
RESULTS: After a median [inter-quartile range] follow-up of 5.8 [3.8-7.8] years, 718 of 8,748 patients (8.2%) had received a diagnosis of cancer. On unadjusted Kaplan-Meier survival analyses cancer incidence was associated with increasing severity of OSA (Log-Rank Test, p<0.0005) and nocturnal hypoxemia (Log-Rank Test, p<0.0001 for both...

Source: Chest - July 2, 2020 Category: Respiratory Medicine Authors: Justeau G, Gervès-Pinquié C, Le Vaillant M, Trzepizur W, Meslier N, Goupil F, Pigeanne T, Launois S, Leclair-Visonneau L, Masson P, Bizieux-Thaminy A, Humeau MP, Gosselin C, Blanchard M, Urban T, Gagnadoux F, ERMES study group Tags: Chest Source Type: research