Molecules, Vol. 25, Pages 3101: The Inhibitory Activity of Anthraquinones Against Pathogenic Protozoa, Bacteria, and Fungi and the Relationship to Structure

Molecules, Vol. 25, Pages 3101: The Inhibitory Activity of Anthraquinones Against Pathogenic Protozoa, Bacteria, and Fungi and the Relationship to Structure Molecules doi: 10.3390/molecules25133101 Authors: Mendel Friedman Alexander Xu Rani Lee Daniel N. Nguyen Tina A. Phan Sabrina M. Hamada Rima Panchel Christina C. Tam Jong H. Kim Luisa W. Cheng Kirkwood M. Land Plant-derived anthraquinones were evaluated in cell assays for their inhibitory activities against the parasitic protozoa Trichomonas vaginalis human strain G3 that causes the sexually transmitted disease trichomoniasis in women, Tritrichomonas foetus bovine strain D1 that causes sexually transmitted diseases in farm animals (bulls, cows, and pigs), Tritrichomonas foetus-like strain C1 that causes diarrhea in domestic animals (cats and dogs), and bacteria and fungi. The anthraquinones assessed for their inhibitory activity were anthraquinone, aloe-emodin (1,8-dihydroxy-3-hydroxymethylanthraquinone), anthrarufin (1, 5-dihydroxyanthraquinone), chrysazin (1,8-dihydroxyanthraquinone), emodin (1,3,8-trihydroxy-6-methylanthraquinone), purpurin (1,2,4-trihydroxyanthraquinone), and rhein (1,8-dihydroxy-3-carboxyanthraquinone). Their activities were determined in terms of IC50 values, defined as the concentration that inhibits 50% of the cells under the test conditions and calculated from linear dose response plots for the parasitic protozoa, and zone of inhibition for bacteria and fungi, respecti...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research