Pharmacokinetics of levofloxacin after single intravenous and oral administration, and its interaction with sucralfate in mixed-breed dogs.

Pharmacokinetics of levofloxacin after single intravenous and oral administration, and its interaction with sucralfate in mixed-breed dogs. Xenobiotica. 2020 Jul 06;:1-14 Authors: Urzúa N, Messina MJ, Caverzan M, Prieto G, Lüders C, Errecalde C Abstract The study aims to establish the plasma pharmacokinetic parameters of levofloxacin in mixed-breed dogs, at a single dose of 5 mg/kg, intravenously, orally only and orally with sucralfate pre-treatment (1g per animal), to evaluate its influence on antimicrobial absorption.Concentrations of levofloxacin in plasma were determined using high performance liquid chromatography (HPLC) with fluorescence detection.After iv of levofloxacin, the mean (± SD) of AUC0-24, Vz, t½λz and MRT, were 19.05 ± 6.4 µg-h/ml, 2.43 ± 0.5 L/kg, 7.93 ± 1.41 hours and 8.7 ± 1.5 hours, respectively. After oral administration, a Cmax, t½λz and bioavailability of 1.95 ± 0.7 µg/ml, 7.65 ± 1.38 hours and 71.93 ± 9.75%, respectively.In animals given an oral dose of levofloxacin with sucralfate pre-treatment, a significant decrease (p < 0.05) in Cmax (0.57 ± 0.23 µg/ml), AUC (5.73 ± 2.26 ug-h/ml) and bioavailability (31.92 ± 14.19%).In the dogs studied, it is suggested that the dose 5 mg/kg of levofloxacin for both routes is inadequate to meet PK-PD targets for susceptible bacteria using breakpoints established by the Institute of Clinical and...
Source: Xenobiotica - Category: Research Authors: Tags: Xenobiotica Source Type: research