Extending the translational potential of targeting NO/cGMP‐regulated pathways in the CVS
The discovery of NO as both an endogenous signalling molecule and as a mediator of the cardiovascular effects of organic nitrates was acknowledged in 1998 by the Nobel Prize in Physiology/Medicine. The characterization of its downstream signalling, mediated through stimulation of soluble GC (sGC) and cGMP generation, initiated significant translational interest, but until recently this was almost exclusively embodied by the use of PDE5 inhibitors in erectile dysfunction. Since then, research progress in two areas has contributed to an impressive expansion of the therapeutic targeting of the NO‐sGC‐cGMP axis: first, an increased understanding of the molecular events operating within this complex pathway and second, a better insight into its dys‐regulation and uncoupling in human disease. Already‐approved PDE5 inhibitors and novel, first‐in‐class molecules, which up‐regulate the activity of sGC independently of NO and/or of the enzyme's haem prosthetic group, are undergoing clinical evaluation to treat pulmonary hypertension and myocardial failure. These molecules, as well as combinations or second‐generation compounds, are also being assessed in additional experimental disease models and in patients in a wide spectrum of novel indications, such as endotoxic shock, diabetic cardiomyopathy and Becker's muscular dystrophy. There is well‐founded optimism that the modulation of the NO‐sGC‐cGMP pathway will sustain the development of an increasing number of suc...
CONCLUSION: Patients with thyroid disease were found to have a higher risk for uveitis. For certain age groups or patients without diabetes or hypertension, the role of thyroid disease might be more crucial for uveitis development. PMID: 32643974 [PubMed - as supplied by publisher]
Authors: Okosun IS, Nkemjika S, Okosun B, Lyn R, Airhihenbuwa CO Abstract AIM: To determine differences in lifestyle modification practices and use of prescription drugs in a representative sample of Mexican American (MA), non-Hispanic White (NHW), and non-Hispanic Black (NHB) elderly Americans with metabolic syndrome (MetS). METHODS: Data from the United States National Health and Nutritional Examination Surveys were used in this study. Lifestyle modification practices include ongoing physical activity, weight control, and ongoing diet modifications. Prescription drugs include anti-diabetic, anti-obesity, lipi...
HIGH blood pressure is a key risk factor for developing cardiovascular disease. A new research study has identified a certain type of berry that could slash the chances of developing the illness.
Publication date: 11–17 July 2020Source: The Lancet, Volume 396, Issue 10244Author(s): Deepak L Bhatt, Philippe Gabriel Steg
Publication date: 11–17 July 2020Source: The Lancet, Volume 396, Issue 10244Author(s): Gerald Chi, Jolanta Marszalek
CONCLUSIONS: Thawing rate was a novel predictor of acute PVI and the ITR15 was the most valuable predictor of acute PVI. In addition, ITR15 was a predictive factor ensuring long-term PVI (vagus reflex). Our study showed that thawing rate may serve in th e early identification of useless cryoballoon ablation.
Publication date: Available online 9 July 2020Source: The Lancet Diabetes &EndocrinologyAuthor(s): S Le Brocq, K Clare, M Bryant, K Roberts, AA Tahrani, writing group form Obesity UK, Obesity Empowerment Network, UK Association for the Study of Obesity
Publication date: Available online 10 July 2020Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Joseph G. Verbalis
Publication date: September 2020Source: Biomedicine &Pharmacotherapy, Volume 129Author(s): Fang Yang, Qingsong Qu, Chongyan Zhao, Xing Liu, Pengshuo Yang, Zhixun Li, Lu Han, Xinyuan Shi
Publication date: September 2020Source: Biomedicine &Pharmacotherapy, Volume 129Author(s): Lindokuhle Patience Mabuza, Mlindeli Wilkinson Gamede, Sanam Maikoo, Irvin Noel Booysen, Phikelelani Siphosethu Ngubane, Andile Khathi