Platelet C-Type Lectin-Like Receptor 2 Reduces Cholestatic Liver Injury in Mice

This study focused on the functions of the C-type lectin-like receptor 2 (CLEC-2), a new special platelet receptor that binds with podoplanin-activating platelets. The role of CLEC-2 and podoplanin in cholestatic liver injury was investigated. Mice were injected intraperitoneally with weekly doses of anti –CLEC-2 antibody (2A2B10) to achieve effective CLEC-2 inhibition in their platelets.

Source: American Journal of Pathology - May 27, 2020 Category: Pathology Authors: Suguru Maruyama, Hiroshi Kono, Shinji Furuya, Hiroki Shimizu, Ryo Saito, Katsutoshi Shoda, Hidenori Akaike, Naohiro Hosomura, Yoshihiko Kawaguchi, Hidetake Amemiya, Hiromichi Kawaida, Makoto Sudo, Shingo Inoue, Toshiaki Shirai, Katsue Suzuki-Inoue, Daisuk Tags: Regular article Source Type: research