Myogenic cell expression of intercellular adhesion molecule-1 (ICAM-1) contributes to muscle regeneration after injury

We investigated intercellular adhesion molecule-1 (ICAM-1), a membrane protein that mediates cell-to-cell adhesion and communication, as a mechanism through which the inflammatory response facilitates muscle regeneration after injury. Toxin-induced muscle injury to tibialis anterior muscles of wild type mice caused ICAM-1 to be expressed by a population of satellite cells/myoblasts and myofibers. Myogenic cell expression of ICAM-1 contributed to the restoration of muscle structure after injury, as regenerating myofibers were more abundant and myofiber size was larger for wild type compared to ICAM-1-/- mice during 28 d of recovery.

Source: American Journal of Pathology - July 6, 2020 Category: Pathology Authors: Ryan A. Martin, Kole H. Buckley, Drew C. Mankowski, Benjamin M. Riley, Alena N. Sidwell, Stephanie L. Douglas, Randall G. Worth, Francis X. Pizza Tags: Regular Article Source Type: research