Cancers, Vol. 12, Pages 1825: Unique Spatial Immune Profiling in Pancreatic Ductal Adenocarcinoma with Enrichment of Exhausted and Senescent T Cells and Diffused CD47-SIRP α Expression

Conclusion: This study reveals the existence of dysfunctional T lymphocytes with specific spatial distribution, thus opening a new dimension both conceptually and mechanistically in tumor-stroma interaction in PDAC with potential impact on the efficacy of immune-regulatory therapeutic modalities.

Source: Cancers - July 6, 2020 Category: Cancer & Oncology Authors: Alexandros Papalampros Michail Vailas Konstantinos Ntostoglou Maria Lopez Chiloeches Stratigoula Sakellariou Niki V. Chouliari Menelaos G. Samaras Paraskevi D. Veltsista Sofia D. P. Theodorou Aggelos T. Margetis Anna Bergonzini Lysandros Karydakis Natasha Tags: Article Source Type: research