Engineering extracellular matrix to improve drug delivery for cancer therapy.

Engineering extracellular matrix to improve drug delivery for cancer therapy.
Drug Discov Today. 2020 Jul 03;:
Authors: He X, Yang Y, Li L, Zhang P, Guo H, Liu N, Yang X, Xu F
Abstract
As an effective platform to deliver therapeutic drugs into tumors, nanoparticles (NPs) have shown great potential for cancer therapy. However, the tumor microenvironment (TME) contains diverse barriers to the transport of NPs, particularly the dense extracellular matrix (ECM). Thus, engineering the tumor ECM is a promising way to improve drug delivery by degrading existing ECM and/or blocking ECM synthesis. In this review, we present the state-of-the-art advances in engineering the tumor ECM to improve the therapeutic efficacy of NPs, and highlight their advantages and limitations.
PMID: 32629171 [PubMed - as supplied by publisher]

Source: Drug Discovery Today - July 2, 2020 Category: Drugs & Pharmacology Authors: He X, Yang Y, Li L, Zhang P, Guo H, Liu N, Yang X, Xu F Tags: Drug Discov Today Source Type: research