Incidence and outcome of Spitzoid Tumour of Unknown Malignant Potential (STUMP). An analysis of cases in the Netherlands from 1999 till 2014.

Incidence and outcome of Spitzoid Tumour of Unknown Malignant Potential (STUMP). An analysis of cases in the Netherlands from 1999 till 2014. Br J Dermatol. 2020 Jul 06;: Authors: Ruijter CGH, Ouwerkerk W, Jaspars EH, van Doorn R, Luiten RM, Bekkenk MW, Tio DCKS Abstract Spitz naevi are spindle and epithelioid cell melanocytic proliferations that Sophie Spitz first described in 1948 as "juvenile melanomas" [1]. The broader group of Spitzoid proliferations is thought to comprise a biological spectrum with benign Spitz naevi, intermediate lesions and malignant Spitzoid melanomas. Intermediate lesions are known by various synonyms such as atypical Spitz tumours (AST) and Spitzoid tumours of unknown malignant potential (STUMP). These intermediate lesions share features of both Spitz naevi and Spitzoid melanomas. Subsequently they represent a diagnostic grey zone and a clinically challenging group [2, 3]. Biological behaviour and clinical course of this intermediate group still remains largely unknown. This results in a clinical challenge regarding the management of AST/STUMP. In an earlier study on Spitzoid proliferations in children and adolescents Bartenstein et al. reported that Spitzoid proliferations very frequently have benign outcomes [3]. PMID: 32628276 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research