Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome-Associated Cardiomyopathy.

Conclusions: Our study revealed the human cardiac pathogenesis in patient-specific iPSC-CMs from NS patients carrying biallelic variants in LZTR1 and identified a unique disease-specific proteome signature. In addition, we identified the intronic CRISPR repair as a personalized and in our view clinically translatable therapeutic strategy to treat NS-associated HCM. PMID: 32623905 [PubMed - as supplied by publisher]
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research

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Background and Purpose: Accidents, both intentional and unintentional, are one of the leading causes of death and disability for children around the world and impose a heavy financial burden on the health care system of societies. The aim of the present st...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Road accidents are one of the causes of disability, injury and death. As per the latest road accident data released by the Ministry of Road Transport&Highways (MoRTH), the total number of accidents increased by 2.5 percent from 4,89,400 in 2014 to 5,01,4...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news
Today's open access paper outlines an investigation into how the aging of hematopoietic stem cell populations in bone marrow, responsible for producing blood and immune cells, can contribute to age-related dysfunction in the brain. The authors find that detrimental effects are mediated by circulating levels of CyPA, a signaling factor that is a part of the senescence-associated secretory phenotype (SASP), an inflammatory mix of signal molecules produced by senescent cells. The focus here is on direct inhibition of CyPA as an approach to therapy, but senolytic treatments to clear senescent cells may be the more useful appro...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
This article was first published by the UN Chronicle on 6 July 2020.   Follow @IPSNewsUNBureau !function(d,s,id){var js,fjs=d.getElementsByTagName(s)[0],p=/^http:/.test(d.location)?'http':'https';if(!d.getElementById(id)){js=d.createElement(s);;js.src=p+'://';fjs.parentNode.insertBefore(js,fjs);}}(document, 'script', 'twitter-wjs'); The post The UN General Assembly: A 75-Year Journey Towards the Future We Want appeared first on Inter Press Service. Excerpt: Tijjani Muhammad-Bande is President of the 74th Session of the United Nations General Assembly and Permanent Representat...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Development & Aid Gender Global Headlines Health Human Rights Humanitarian Emergencies IPS UN: Inside the Glasshouse Peace TerraViva United Nations UN at 75 Source Type: news
Credit: Unsplash / Lynda Hinton By Kaveh Zahedi and Van NguyenBANGKOK, Thailand, Aug 4 2020 (IPS) After decades of impressive growth, for the first time, Southeast Asia is experiencing a drop in measured human development. The economic fallout from the COVID-19 pandemic will likely take months to reveal itself and years to put right. Yet, a legacy of mobilizing under constraints is leading Southeast Asia’s pandemic response. During the first two months of COVID-19 lockdown, the once bustling streets of Bangkok were unusually quiet. In the alley nested between two high-end shopping malls in downtown Bangkok, an elder...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Asia-Pacific Development & Aid Economy & Trade Education Financial Crisis Headlines Health Human Rights Humanitarian Emergencies Labour Poverty & SDGs TerraViva United Nations Source Type: news
Conditions:   Disability Physical;   Disabilities Multiple;   Disability Hearing;   Disability, Vision;   Disability, Intellectual Intervention:   Other: 'Attitudes towards people with disability Scale' Sponsors:   University of Extremadura;   University of Cadiz Completed
Source: - Category: Research Source Type: clinical trials
Condition:   Castration-Resistant Prostatic Cancer Interventions:   Drug: Niraparib;   Drug: Abiraterone acetate (AA);   Drug: Prednisone;   Drug: Placebo for Niraparib Sponsor:   Janssen Research & Development, LLC Not yet recruiting
Source: - Category: Research Source Type: clinical trials
This article is adapted from Jessica Helfand’s book “Face,” an elaborately illustrated A to Z of the face, from historical mugshots to Instagram posts. Hardly the first to postulate on the graphic evidence of the grimace, Darwin hoped to introduce a system by which facial expressions might be properly evaluated. He shared with many of his generation a predisposition toward history: simply put, the idea that certain facial traits might have a basis in evolution. Empirically, the idea itself is not unreasonable. We are, after all, genetically predisposed to share traits with those in our familial line, occa...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Psychology syndication Source Type: news
Conclusions: CMS may misvalue payment and wRVU rates of hospital-based hand procedures due to inaccurate operative time estimates. By identifying which procedures are misvalued in terms of payment and wRVU per operative time, providers and payors may be able to address these imbalances and maximize appropriate care delivery incentives.Level of Evidence: III. PMID: 32742227 [PubMed - in process]
Source: Iowa orthopaedic journal - Category: Orthopaedics Tags: Iowa Orthop J Source Type: research
Conclusion: Sarcopenia is an independent risk factor for fracture nonunion following operative fixation of open tibia or ankle fracture, but is not predictive of surgical site infection. Gustilo Anderson classification is strongly associated with SSI risk. Psoas index is a straightforward and objective method of identifying sarcopenia in patients with open fractures. Diagnosing sarcopenia in these individuals can inform medical decision making and patient counseling regarding risk for nonunion. Further work is needed to identify effective interventions to improve outcomes in these patients.Level of Evidence: III. PMID:...
Source: Iowa orthopaedic journal - Category: Orthopaedics Tags: Iowa Orthop J Source Type: research
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