Heightened Exploratory Behavior Following Chronic Excessive Ethanol Drinking: Mediation by Neurotensin Receptor Type 2 in the Anterior Paraventricular Thalamus.

CONCLUSIONS: Our findings suggest that chronic, excessive, but not lower level, ethanol drinking induces heightened or flexible exploratory behavior, which predicts future ethanol drinking and is partly mediated by elevated NTS2R signaling in the aPVT. These ethanol-induced alterations represent adaptations that could perpetuate excessive drinking and lead to the development of ethanol dependence. PMID: 32623746 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Tags: Alcohol Clin Exp Res Source Type: research