Stable Low-Dose Oxygen Release Using H2O2/Perfluoropentane Phase-Change Nanoparticles with Low-Intensity Focused Ultrasound for Coronary Thrombolysis

After the onset of myocardial infarction, extensive coronary thrombus and oxygen supply insufficiency lead to severe myocardial damage and heart failure. Recently, ultrasound-irradiated phase-change nanoparticles have been recognized for their cardiovascular thrombolysis potential. Therefore, we sought to establish a novel treatment method using hydrogen peroxide (H2O2)/perfluoropentane (PFP) phase-change nanoparticles with low-intensity focused ultrasound (LIFU) for the simulation of acute coronary thrombolysis and myocardial preservation.

Source: Ultrasound in Medicine and Biology - July 5, 2020 Category: Radiology Authors: Nan Jiang, Bo Hu, Sheng Cao, Shunji Gao, Qingqiong Cao, Jinling Chen, Qing Zhou, Ruiqiang Guo Tags: Original Contribution Source Type: research