NK cells contribute to hepatic CD8+ T cell failure in hepatitis B virus-carrier mice after alcohol consumption.

In conclusion, alcohol abuse induces CD8+ T cells failure after acute HBV infection, but depletion of NK cells could retore CD8+ T cell activity. Moreover, downregulation of energy metabolism and upregulation of oxidative stress may also contribute to CD8+ T cell failure.
PMID: 32622853 [PubMed - as supplied by publisher]

Source: Virus Research - July 1, 2020 Category: Virology Authors: Jiang S, Zhu Y, Cheng C, Li Y, Ma T, Peng Z, Li Q, Xu J, Xu L Tags: Virus Res Source Type: research