The Ubiquitin Enigma: Progress in the Detection and Chemical Synthesis of Branched Ubiquitin Chains.

The Ubiquitin Enigma: Progress in the Detection and Chemical Synthesis of Branched Ubiquitin Chains.
Chembiochem. 2020 Jul 04;:
Authors: Li Y, Hua X, Chu G
Abstract
Ubiquitin chains with distinct topologies play essential roles in eukaryotic cells. Recently, it was discovered that multiple ubiquitin units can be ligated to more than one lysine residue in the same ubiquitin to form diverse branched ubiquitin chains. Although there is increasing evidence implicating these branched chains in a plethora of biological functions, few mechanistic details have been elucidated. This concept article introduces the function, detection and chemical synthesis of branched ubiquitin chains; and offers some future perspective for this exciting new field.
PMID: 32621561 [PubMed - as supplied by publisher]

Source: Chembiochem - July 3, 2020 Category: Biochemistry Authors: Li Y, Hua X, Chu G Tags: Chembiochem Source Type: research