MicroRNA-199a-3p inhibits angiogenesis by targeting the VEGF/PI3K/AKT signalling pathway in an in vitro model of diabetic retinopathy.

CONCLUSION: MiR-199a-3p upregulation ameliorated HG-stimulated angiogenesis of hRMECs by modulating the PI3K/AKT pathway through inhibiting VEGF. Although retinal neovascularization in vivo has not been studied, these in vitro findings provide more evidence for the role of miR-199a-3p upregulation against HG-induced angiogenesis. PMID: 32622012 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32622012?dopt=Abstract

Source: Experimental and Molecular Pathology - June 30, 2020 Category: Pathology Authors: Wang L, Liu WX, Huang XG Tags: Exp Mol Pathol Source Type: research